"Numerous micronutrients naturally abundant in oilseeds prevent the risk of cardiovascular diseases by reducing cholesterolemia and oxidative stress.
These micronutrients include phytosterols and various antioxidants such as polyphenols, tocopherols and coenzyme Q10/Q9 but most of them are lost during the oilseed oil refining.
The main objective of the Optim’Oil project was to modify the processes of oil refining in order to reduce the lost of micronutrients.
Two clinical trials (cross-over, monocentric, randomized, double-blind and controlled) were designed to investigate the effect of an optimized rapeseed oil 1) on cardiovascular biomarkers (long-term study) and 2) on oxidative stress parameters (post-prandial study).
For the long-term study, 59 volunteers ingested daily 20g of oil and 22g of margarine (optimized or standard) for 2 periods of 3weeks separated by a 3-week wash-out period."

L’article "Preservation of micronutrients during rapeseed oil refining : A tool to optimize the health value of edible vegetable oils ? Rationale and design of the Optim’Oils randomized clinical trial" a été co-écrit par Gladine C, Meunier N, Blot A, Bruchet L, Pagès X, Gaud M, Floter E, Metin Z, Rossignol A, Cano N, Chardigny JM.

Il est paru en novembre 2010 dans la revue "Contemporary clinical trials".